Myoclonus – Medical Marijuana Research Overview
The following information is presented for educational purposes only. Higher Society of Indiana Inc. provides this information to provide an understanding of the potential applications of cannabidiol. Links to third party websites do not constitute an endorsement of these organizations by Higher Society of Indiana Inc. and none should be inferred.
Myoclonus is the quick, jerky contraction of an individual or group of muscles that is often caused by an underlying health condition. Studies suggest that cannabis lowers neuronal excitability and thus can potentially reduce involuntary contractions.
Overview of Myoclonus
Myoclonus is a symptom characterized by a sudden, involuntary muscle jerk. Myoclonic twitches can involve a single muscle or a group of muscles and can feature a single twitch or contractions that happen a sequence and repeat at various speeds. In some cases, myoclonus can cause a person to experience persistent, shock-like contractions in a group of muscles. Severe cases can severely limit the ability to eat, talk or walk.
The types of myoclonus can be classified as physiological, essential, epileptic, or symptomatic (secondary). The most common form of myoclonus is symptomatic, which occurs as a result of some underlying condition, such as a neurological disorder, a reaction to a medication, prolonged oxygen deprivation, kidney or liver failure, infection, head or spinal cord injury, or a metabolic condition. It’s not uncommon for multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, or epileptic patients to develop myoclonus. Healthy individuals experience physiological myoclonus, such as hiccups or jerking suddenly just before falling asleep, and do not need to be treated. Essential myoclonus occurs on its own, unrelated to an underlying illness and typically without other symptoms. Epileptic myoclonus occurs in association with an epileptic disorder.
According to the National Institute of Neurological Disorders and Stroke, most myoclonus is caused by a disturbance of the central nervous system. Scientists think that over-excitability of the motor pathways that control movement is responsible for symptoms. Abnormalities or deficiencies in the receptors of certain neurotransmitters may also be involved.
Treatment of myoclonus varies depending on its type and whether there is a treatable underlying condition. In the cases where the underlying condition can be fixed, such as changing the medication that causes jerking, myoclonus symptoms can be eliminated. However, most underlying causes cannot be cured or eliminated, so treatment efforts focus on easing myoclonus symptoms with anticonvulsant or tranquilizer medications. Botox injections can be helpful in treating myoclonus when it occurs in a single area. Surgery may be necessary when myoclonus is caused by a tumor or lesion on the brain or spinal cord.
Findings: Effects of Cannabis on Myoclonus
Research looking into cannabis’ direct effect on myoclonus is lacking. However, cannabis has been shown to have anticonvulsant and antiseizure effects. Multiple scientific reviews conclude that a major cannabinoid found in cannabis, cannabidiol (CBD), has demonstrated the ability to reduce or even eliminate seizures (Blair, Deshpande & DeLorenzo, 2015) (Rosenberg, Tsien, Whalley & Devinsky, 2015) (Szaflarski & Bebin, 2014) (Devinsky, et al., 2014). In preclinical trials, the administration of CBD and other cannabis cannabinoids have shown to provide significant anticonvulsant effects in mice and rats (Turkansis, et al., 1979) (Hill, et al., 2013). Most of the traditional medications used to treat myoclonus are also used to treat epilepsy, which suggests that cannabis, already demonstrating effective for epilepsy, may also prove beneficial for myoclonus.
CBD’s ability to decrease or eliminate seizures is due to its effects on the endocannabinoid system. CBD activates cannabinoid receptor 1 (CB1); The CB1 receptor then dampens neurotransmission and produces an overall reduction in neuronal excitability (Wallace, Wiley, Martin & DeLorenzo, 2001) (Hoffman & Frazier, 2013). This finding suggests that CBD may be able to combat myoclonus caused by over excitability.
Cannabinoids have also proven beneficial for curtailing tics and tremors in movement disorders like Parkinson’s disease and Huntington’s disease (Kluger, Triolo, Jones & Jankovic, 2015) (Fernandez-Ruiz, 2009) (Fernandez-Ruiz & Gonzales, 2005). Researchers suggest that cannabinoids may help alleviate involuntary motor symptoms because both CB1 and CB2 receptors, which cannabinoids act upon, have been found to be located in the basal ganglia and cerebellum. These are areas of the brain that control movement (Fernandez-Ruiz & Gonzales, 2005).
States That Have Approved Medical Marijuana for Myoclonus
Currently, only the state of Illinois has approved medical marijuana specifically for the treatment of myoclonus. However, in Washington D.C., any condition can be approved for medical marijuana as long as a DC-licensed physician recommends the treatment. In addition, a number of other states will consider allowing medical marijuana to be used for the treatment of myoclonus with the recommendation from a physician. These states include: California (any debilitating illness where the medical use of marijuana has been recommended by a physician), Connecticut (other medical conditions may be approved by the Department of Consumer Protection), Massachusetts (other conditions as determined in writing by a qualifying patient’s physician), Nevada (other conditions subject to approval), Oregon (other conditions subject to approval), Rhode Island (other conditions subject to approval), and Washington (any “terminal or debilitating condition”).
Twenty-five states have approved medical marijuana specifically to treat epilepsy. These states include: Alabama (debilitating epileptic conditions), Connecticut, Delaware (intractable epilepsy), Florida, Georgia (seizure disorder), Iowa (intractable epilepsy), Louisiana, Maine, Mississippi (intractable epilepsy), Missouri (intractable epilepsy), New Hampshire, New Jersey (seizure disorders), New Mexico, New York, North Carolina (intractable epilepsy), North Dakota, Ohio, Oklahoma (pediatric epilepsy), Pennsylvania, South Carolina (Dravet syndrome, Lennox-Gastaut syndrome, Refractory epilepsy), Texas (intractable epilepsy), Utah (intractable epilepsy), Virginia (intractable epilepsy), Wisconsin (seizure disorders), and Wyoming (intractable epilepsy).
Several states have approved medical marijuana to treat seizures or seizure disorders. These states include: Alaska, Arizona, Arkansas, California, Colorado, Delaware, Hawaii, Louisiana, Maryland, Michigan, Minnesota, Montana, Nevada, New Hampshire, North Dakota, Ohio, Oregon, Pennsylvania (intractable seizures), Rhode Island, Tennessee (intractable seizures), Vermont and Washington.
Sixteen states have approved medical marijuana for the treatment of spasms. These states include: Arizona, Arkansas, California, Colorado, Delaware, Florida, Hawaii, Maryland, Michigan, Minnesota, Montana, Nevada, New Hampshire, Oregon, Rhode Island and Washington.
Recent Studies on Cannabis’ Effect on Myoclonus
- Cannabis provided significant anticonvulsant effects in mice and rats.
Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
- Preliminary evidence shows that CBD may be useful as an anticonvulsant.
Cannabinoids: is there a potential treatment role in epilepsy?
Blair, R.E., Deshpande, L.S., and DeLorenzo, R.J. (2015, September). Cannabinoids: is there a potential treatment role in epilepsy? Expert Opinion on Pharmacology, 16(13), 1911-4.
Devinsky, O., Cilio, M.R., Cross, H., Fernandez-Ruiz, J., French, J., Hill, C., Katz, R., Di Marzo, V., Jutras-Aswad, D., Notcutt, W.G., Martinez-Orgado, J., Robson, P.J., Rohrback, B.G., Thiele, E., Whalley, B., and Friedman, D. (2014, June). Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, 55(6), 791-802.
Fernandez-Ruiz, J. (2009, April). The endocannabinoid system as a target for the treatment of motor dysfunction. British Journal of Pharmacology, 156(7), 1029-40.
Fernandez-Ruiz, J., and Gonzales, S. (2005). Cannabinoid control of motor function at the basal ganglia. Handbook of Experimental Pharmacology, 168, 479-507.
Hill, T.D., Cascio, M.G., Romano, B., Duncan, M., Pertwee, R.G., Williams, C.M., Whalley, B.J., and Hill, A.J. (2013, October). Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. British Journal of Pharmacology, 170(3), 679-92.
Hoffman, M.E., and Frazier, C.J. (2013, June). Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention. Experimental Neurology, 244, 43-50.
Myoclonus. (2012, December 20). Mayo Clinic. Retrieved from http://www.mayoclinic.org/diseases-conditions/myoclonus/basics/definition/con-20027364.
Myoclonus Fact Sheet. (2015, February 23). National Institute of Neurological Disorders and Stroke. Retrieved from http://www.ninds.nih.gov/disorders/myoclonus/detail_myoclonus.htm.
Rosenberg, E.C., Tsien, R.W., Whalley, B.J., and Devinsky, O. (2015, August 18). Cannabinoids and Epilepsy. Neurotherapeutics, Epub ahead of print. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/26282273.
Szaflarski, J.P. and Bebin, E.M. (2014, December). Cannabis, cannabidiol, and epilepsy–from receptors to clinical response. Epilepsy & Behavior, 41, 277-82.
Turkanis, S.A., Smiley, K.A., Borys, H.K., Olsen, D.M., and Karler, R. (1979, August). An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats. Epilepsia, 20(4), 351-63.
Wallace, M.J., Wiley, J.L., Martin, B.R., and DeLorenzo, R.J. (2001, September 28). Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. European Journal of Pharmacology, 428(1), 51-7.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.